PPD
The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in
the United States A Joint Statement by the Advisory Council for the Elimination
of Tuberculosis and the Advisory Committee on Immunization Practices (MMWR
45(RR-4);1-18) for information on topic Tuberculin Skin Testing and Interpretation
of Results After BCG Vaccination :
The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in
the United States A Joint Statement by the Advisory Council for the Elimination
of Tuberculosis and the Advisory Committee on Immunization Practices (MMWR
45(RR-4);1-18) for information on topic Tuberculin Skin Testing and Interpretation
of Results After BCG Vaccination
Postvaccination BCG-induced tuberculin reactivity ranges from no induration
to an induration of 19 mm at the skin-test site (65-74). Tuberculin reactivity
caused by BCG vaccination wanes with the passage of time and is unlikely to
persist >10 years after vaccination in the absence of M. tuberculosis exposure
and infection. BCG-induced reactivity that has weakened might be boosted by
administering a tuberculin skin test 1 week to 1 year after the initial postvaccination
skin test; ongoing periodic skin testing also might prolong reactivity to
tuberculin in vaccinated persons (70,72).
Screening for Tuberculosis and Tuberculosis Infection in High-Risk Populations
Recommendations of the Advisory Council for the Elimination of Tuberculosis
(MMWR 44(RR-11);18-34) for information concerning Summary of interpretation
of tuberculin skin-test results :
Screening for Tuberculosis and Tuberculosis Infection in High-Risk Populations
Recommendations of the Advisory Council for the Elimination of Tuberculosis
(MMWR 44(RR-11);18-34) for information concerning Summary of interpretation
of tuberculin skin-test results :
1. An induration of >=5 mm is classified as positive in the following:
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• Persons who have had recent close contact with persons who have
active TB;
• Persons who have human immunodeficiency virus (HIV) infection
or risk factors for HIV infection but unknown HIV status;
• Persons who have fibrotic chest radiographs consistent with
healed TB.
2. An induration of >=10 mm is classified as positive in all persons
who do not meet any of the above criteria, but who belong to one or more of
the following groups having high risk for TB:
• Injecting-drug users known to be HIV seronegative
• Persons who have other medical conditions that have been reported
to increase the risk for progressing from latent TB infection to active TB.
• These medical conditions include diabetes mellitus, conditions
requiring prolonged high-dose corticosteroid therapy and other immunosuppressive
therapy (including bone marrow and organ trans- plantation), chronic renal
failure, some hematologic disorders (e.g., leukemias and lymphomas), other
specific malignancies (e.g., carci- noma of the head or neck), weight loss
of >= 10% below ideal body weight, silicosis, gastrectomy, jejunoileal
bypass
• Residents and employees of high-risk congregate settings: prisons
and jails, nursing homes and other long-term facilities for the elderly, health-care
facilities (including some residential mental health facili- ties), and homeless
shelters
• Foreign-born persons recently arrived (i.e., within the last
5 years) from countries having a high prevalence or incidence of TB
• Some medically underserved, low-income populations, including
mi- grant farm workers and homeless persons
• High-risk racial or ethnic minority populations, as defined
locally
• Children <4 years of age or infants, children, and adolescents
exposed to adults in high-risk categories.
3. An induration of >=15 mm is classified as positive in persons
who do not meet any of the above criteria.
Campus Resources :
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