Current Research Interests:
Cytokine gene expression in nervous system in inflammation and infection, Detection of low-level chronic infection in nervous tissue, Importance in anti-cyokine immune response in therapy of autoimmunity with recombinant cytokines.

Representative Publications:
Pachner, A.R., Cadavid, D., Shu, G., Dail, D., Pachner, S., Hodzic, E., and Barthold, S.W., Central and peripheral nervous system infection, immunity, and inflammation in the NHP model of Lyme borreliosis, Ann Neurol 50:330-338, 2001

Pachner, A.R., Measurement of antibodies to interferon beta in patients with multiple sclerosis. Arch Neurol. 2001 Aug;58(8):1299-300.

Pachner, A.R., Amemiya, K., Bartlett , M., Schaefer,H., Reddy, K., Zhang, W.-F. Lyme borreliosis in Rhesus macaques- effect of corticosteroids on spirochetal load and isotype switching of anti-Borrelia burgdorferi. Clinical and Diagnostic Laboratory Immunology 8:225-232, 2001

Cadavid D, Pachner AR, Estanislao L, Patalapati R, Barbour AG, Isogenic Serotypes of Borrelia turicatae Show Different Localization in the Brain and Skin of Mice. Infect Immun;69:3389-3397, 2001

Pachner, A.R., The immunobiology of the Rhesus macaque model for Lyme neuroborreliosis, Immunological Reviews, 183:186-204, 2001

Pachner, A.R. , Gelderblom, H., "The prognosis of spirochetal infections", in Prognosis of Neurological Disease, ed. Evans,R., Baskin,D.C., Yatsu,F.M., Oxford University Press, in press, 2001

Pachner, A.R., Cadavid, D., Chapters 28(Lyme neuroborreliosis), 28A(Neurosyphilis) and 28B(Neuroborreliosis in relapsing fever), Baker's Clinical Neurology, in press for 2002

Pachner, A.R., Dail, D., Narayan, K., Dutta, K., and Cadavid, D., Lyme myositis: increased expression of B-lymphocyte chemoattractant (BLC) in the rhesus model of Lyme borreliosis, submitted