Current Research Interests/Projects:

I conduct research in the area of psychoneuroimmunology, focusing on the neurochemical and behavioral consequences of immunological challenge, cytokine administration, and stressor exposure. Particular attention is being focused on the mechanisms by which cytokines (e.g., interleukin-2) influence neurochemical activity in the mesocorticolimbic system, and induce behavioral abnormalities that are associated with aberrations in this neural system. I am also interested in relationships between stressful events, the sympathetic nervous system and peripheral immunity.

Representative Publications:

Zalcman, S., Green Johnson, J.M., Murray , L., J.M., Nance, D.M., Dyck, D.G., Anisman,
H. and Greenberg, A. H. (1994). Cytokine specific central monoamine alterations
induced by interleukin (IL) l, IL 2 and IL 6. Brain Research, 643, 40 49.

Zalcman, S., Green Johnson, J.M., Murray , L., Wan, W., J.M., Nance, D.M., &
Greenberg A.H. (1994). Interleukin 2 induced enhancement of an antigen specific IgM
PFC response is mediated by the sympathetic nervous system. Journal of Pharmacology
and Experimental Therapeutics, 271, 977 982

Green Johnson, J.M., Zalcman, S., Vriend, C. Y., Dolina, S., Nance, D.M., & Greenberg,
A.H. (1996). Role of norepinephrine in suppressed IgG production in epilepsy prone
mice. Life Sciences, 59, (14), 1121-1132.

Zalcman, S., Murray , L., Dyck, D.G., Greenberg, D.G., & Nance, D.M. (1998).
Interleukin (IL)-2 and IL-6 induce behavioral-activating effects in mice. Brain Research,
811, 111-121.

Zalcman, S., Savina, I. , & Wise, R.A. (1999). Interleukin-6 increases sensitivity to the
locomotor-stimulating effects of amphetamine in rats. Brain Research 847, 276-283.