Pharmacology & Physiology

BIOGRAPHICAL SKETCH

 

NAME:                                                        POSITION TITLE:

Madalina Condrescu , Ph.D.                          Assistant Professor

 

INSTITUTION AND LOCATION                    DEGREE      YEAR(S)      FIELD OF STUDY

                        

Univ. of Bucharest, Bucharest , Romina         B.S.            1963-1968     Physics

Instituto Venezolano de Investigaciones         M.S.           1974-1976     Physiology &

Cientificas IVIC, Caracas, Venezuela                                                   Biophysics

Instituto Venezolano de Investigaciones         Ph.D.          1976-1979     Physiology &

Cientificas IVIC, Caracas, Venezuela                                                   Biophysics

Roche Institute of Molecular Biology,             Postdoc      1990-1993    

Department of Gene Regulation, Nutely, NJ

 

A.   Positions and Honors

UNIVERSITY APPOINTMENTS

7/1979 - 8/1988       Centro de Biofisica y Bioquimica, Instituto Venezolano

8/1988 - 10/1992      Research Associate - Centro de Biofisica y Bioquimica, Instituto

                              Venezolano de Investigaciones Cientificas IVIC, Assoc.

                              Investigator, de Investigaciones Cientificas IVIC

                             

1/1994 - 9/1998       Research Teacing Specialist II, Dept. of Physiology,

                              UMDNJ - New Jersey Medical School

9/1998 - present      Assistant Professor, Dept. of Pharmacology & Physiology,

                             UMDNJ - New Nersey Medical School                  

AWARDS AND HONORS

1974-1976              M.S. Fellow, Instituto Venezolano de Investigaciones Cientificas IVIC.

1976-1979              Ph.D. Fellow, Instituto Venezolano de Investigaciones Cientificas IVIC.

1979                      Ph.D., Physiology and Biophysics "Magna cum Laudae"

1990-1993              Postdoctoral Fellow, Roche Institute of Molecular Biology.

MEMBERSHIPS, OFFICES AND COMMITTE ASSIGNMENTS

Biophysical Society

American Association for the Advancement of Science

Sociedad de Biofisicos Latinoamericanos SOBLA

ARTICLES

1. Reeves, J.P. and Condrescu, M. (2008) Ionic Regulation of the Cardiac Sodium-Calcium

    Exchanger. Channels 2 (Epub ahead of print)

   

2. Chernysh, O., Condrescu, M. and Reeves, J. P. (2008) Sodium-dependent inactivation

    of sodium-calcium exchange in transfected Chinese hamster ovary cells.American Journal

    of Physiology Cell Physiology:   295 , C872-C882.

  

3. Reeves, J. P., Abdellatif, M. and Condrescu, M. (2008) The sodium-calcium exchanger is

    a mechanosensitive transporter. Journal of Physiology: 586 , 1549-63.

4. Reeves, J.P., Condrescu, M., Urbanczik, J. and Chernysh, O. (2007). New Modes of

    Exchanger Regulation: Physiological Implications. Annals of the NY Academy of

    Sciences: 1099, 64-78.

5. Urbanczyk, J., Chernysh, O., Condrescu, M. and Reeves, J.P. (2006) Sodium-calcium

    exchange does not require allosteric calcium activation at high cytosolic sodium

    concentrations. Journal of Physiology: 575 , 693-705.

    

6. Condrescu, M. and Reeves, J.P. (2006). Actin-dependent regulation of the cardiac

    sodium-calcium exchanger. American Journal of Physiology Cell Physiology:290, C691-C701.

 

ABSTRACTS

1. Reeves, J. P. and Condrescu, M. (2008) The Na/Ca exchanger is a mechanosensitive

    transporter. 52nd Annual Meeting of the Biophysical Society, Long Beach, CA.

      

2. Chernysh, O., Condrescu, M. and Reeves, J.P. (2008) Na-dependent inactivation of

    NCX1 in transfected CHO cells. 52 nd Annual Meeting of the Biophysical Society,

    Long Beach, CA.

   

3. Condrescu, M., Chernysh, O. and Reeves, J.P. (2007) Inhibition of Na/Ca exchange

    activity by KB-R7943 in transfected CHO cells. 51 st Annual Meeting of the Biophysical

    Society, Baltimore, MD.  

 

4. Urbanczyk, J., Condrescu, M. and Reeves, J.P. (2006) KB-R7943 and NCX activity

    in transfected CHO cells. 50 th Conference on Na/Ca exchange, Brussels, Belgium.

 

5. Chernysh, O., Condrescu, M. and Reeves J.P. (2006) PIP2 and hysteresis of allosteric

    Ca activation of Na/Ca exchange: inhibition of persistent Ca activation by the PI kinase

    inhibitor wortmannin. 50th Annual  Meeting of the Biophysical Society, Salt Lake City, Utah.

 

6. Condrescu, M. and Reeves, J.P. (2005) Actin-dependent regulation of the cardiac

    sodium-calcium exchanger. 4 th Mammalian Myocardium Symposium, Bristol, UK.

   

MAJOR RESEARCH INTEREST

I have a general interest in cell calcium homeostasis; a specific interest in the

Sodium-Calcium exchanger NCX1.1 and its role in calcium homeostasis in cardiac

cells. I am also interested in the regulatory properties of NCX1.3, the isoform expressed

in smooth muscle cells and how they differ from those of the cardiac isoform NCX1.1.

GRANT HISTORY

Co-Investigator NIH Grant HL49932