Pharmacology & Physiology
BIOGRAPHICAL SKETCH
NAME Tibor Rohacs, MD, PhD. |
POSITION TITLE
Associate Professor |
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INSTITUTION AND LOCATION |
DEGREE
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YEAR(s) |
FIELD OF STUDY |
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Semmelweis University of Medicine Budapest
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M.D. |
1986-1992 |
Medicine |
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Semmelweis University of Medicine Budapest
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Ph.D. |
1993-1997 |
Cell. Mol. Physiology |
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Columbia University
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1997-1998 |
Molecular Cardiology (postdoc) |
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Mount Sinai School of Medicine |
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1998-2002 |
Ion Channel Physiology (postdoc) |
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Positions
1992 Sept-1997 April
Research Associate, Semmelweis University of Medicine, Department of Physiology
1997 April- 1997 June
Assistant Professor, Semmelweis University of Medicine, Department of Physiology
2002 July- 2005 March
Instructor, Mount Sinai School of Medicine, Department of Physiology and Biophysics
2005 April – 2011 June
Assistant professor, UMDNJ- New Jersey Medical School, Department of Pharmacology and Physiology
2011 July –
Associate Professor with tenure, UMDNJ- New Jersey Medical School, Department of Pharmacology and Physiology
Honors
Research student conferences,
1991, 1st prize, Budapest Competition
1991, 3rd prize, National Competition, Hungary
1992, 2nd prize, Budapest Competition
1992, 1st prize, National Competition, Hungary
Scholarship of the Republic of Hungary (1990-1992)
1993 Pro Scientia Gold Medal
Other Experience and Professional Memberships
Associate Editor, Mount Sinai Journal of Medicine: 2002 – 2006
Advisory Board member: Pflugers Archive 2009 -
ad hoc reviewer for NIH: ZRG1 MDCN-G(91) Special Emphasis Review Committee, 2007
ad hoc reviewer for NSF: Signal Transduction, Molecular and Cellular Biosciences, 2008
ad hoc reviewer for NIH, NTRC study section, 2009
ad hoc mail reviewer for ZRG1 MDCN A (challenge grants), 2009
ad hoc reviewer for Biotechnology and Biological Sciences Research Council – BBSRC, England, UK, 2010
ad hoc reviewer NIH Special Emphasis Panel (SEP, MDCN‐A(05)M) teleconference, 2011
Member, Biophysical Society
Member, Society for Neuroscience
C. Publications
1. A. Spät, I. Balla, T. Balla, P. Enyedi, G. Hajnóczky, and T. Rohács: Sustained stimulation of aldosterone production by angiotensin II is potentiated by nickel. Am. J. Physiol. 258: E555-E561, 1990
2. L. Hunyady, T. Rohács, A. Bagó, F. Deák, and A. Spät: Dihydropyridine-sensitive initial component of the ANG II-induced Ca2+ response in rat adrenal glomerulosa cells. Am. J. Physiol. 266: C67-C72, 1994
3. T. Rohács, A. Bagó, F. Deák, L. Hunyady, and A. Spät: Capacitative Ca2+ influx in adrenal glomerulosa cells. Possible role in angiotensin II response. Am. J. Physiol. 267: C1246-C1252, 1994
4. A. Spät, T. Rohács and L. Hunyady: Plasmalemmal dihydropyridine receptors modify the function of subplasmalemmal inositol 1,4,5-trisphosphate receptors: a hypothesis. Cell Calcium 15: 431-437, 1994
5. G. Szabadkai, A. Horváth, T. Rohács, L. Vimláti, A. Spät and P. Enyedi: Expression of inositol 1,4,5-trisphosphate receptors in rat adrenocortical zones Journal of Steroid Biochemistry and Molecular Biology 57(1-2): 13-17, 1996
6. T. Rohács, G. Nagy and A. Spät: Cytoplasmic Ca2+ signal and reduction of mitochondrial pyridine nucleotides in adrenal glomerulosa cells Biochemical Journal 322: 785-92, 1997
7. T. Rohács, K. Tory, A. Dobos, and A. Spät: Intracellular calcium release is more efficient than calcium influx in stimulating mitochondrial NAD(P)H formation in adrenal glomerulosa cells Biochemical Journal. 328: 525-28 1997
8. T. Rohács, J. Chen, G.D. Prestwich and D.E. Logothetis: Distinct specificities of inwardly rectifying K+ channels for phosphoinositides Journal of Biological Chemistry 274, 36065-72, 1999
9. A. Spät, J. Pitter, T. Rohács and G. Szabadkai: Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells. News Physiol Sci. 16:197-200, 2001
10. T. Rohács, C.M.B. Lopes, T. Mirshahi, T. Jin, H. Zhang and D. E. Logothetis: Assaying PIP2 regulation of potassium channels. Methods in Enzymology 345:71-92, 2002
11. C.M.B. Lopes, H. Zhang, T. Rohács, T. Jin, J.Yang and D. E. Logothetis:
Alterations in Conserved Kir Channel-PIP2 Interactions Underlie Channelopathies Neuron 34, 933–944, 2002
12. T. Jin, L. Peng, T. Rohács, T.Mirshahi, K.W. Chan, R. Sanchez and D.E. Logothetis: The subunits of G proteins gate a K+ channel by pivoted bending of a transmembrane segment. Molecular Cell 10:469-81, 2002
13. T. Rohács, C.M.B. Lopes, T. Jin, P. Ramdya, Z. Molnár and D.E. Logothetis: Phosphoinositide specificity determines lipid regulation of Kir channel activity Proc. Natl. Acad. Sci. USA 100:745-50, 2003
14. H. Zhang, L.C. Craciun, T. Mirshahi, T. Rohács, C.M.B. Lopes, D.E. Logothetis: PIP2 activates KCNQ channels and its hydrolysis underlies receptor mediated inhibition of M-current Neuron 37:963-75, 2003
15. M.B. Meyers, A. Fischer, Y.J. Sun, C.M.B. Lopes, T. Rohács, T. Y. Nakamura, Y.Y. Zhou, P.C. Lee, R.A. Altschuld, S.A. McCune, W.A. Coetzee, G.I. Fishman: Sorcin regulates excitation-contraction coupling in the heart Journal of Biological Chemistry 278: 28865-28871, 2003
16. X. Du, H. Zhang, C.M.B. Lopes, T. Mirshahi, T. Rohács, D.E. Logothetis: Characteristic interactions with PIP2 determine regulation of Kir channels by diverse modulators. J.Biol.Chem. 279:37271-81, 2004
17. C.M.B. Lopes, T. Rohács, G. Czirjak, T. Balla, P. Enyedi, D.E.Logothetis: PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. J.Physiol. 564:117-29, 2005 (contributed equally)
18. T. Rohács, C.M.B. Lopes, I. Michailidis, D.E Logothetis: PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain, Nature Neuroscience 8:626-634, 2005 (corresponding author)
19. T. Rohács: Teaching Resource. TRP channels Science STKE 2005(282):tr14, 2005
20. P. Varnai, B. Thyagarajan, T. Rohacs and T. Balla: Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact cells. J Cell Biol 175: 377-382, 2006.
21. T. Rohacs: PIP2 regulation of TRP channels Pflugers Archive 453(6):753-62, 2007
22. Viktor Lukacs, Baskaran Thyagarajan, Peter Varnai, Andras Balla, Tamas Balla, Tibor Rohacs: Dual regulation of TRPV1 by phosphoinositides J Neurosci 27 (26):7070-80. 2007
23. T. Rohacs, Bernd Nilius: Regulation of Transient Receptor Potential (TRP) channels by phosphoinositides Pflugers Archive 455(1):157-68, 2007
24. Lopes CMB, Remon JI, Matavel A, Sui JL, Keselman I, Medei E, Shen Y, Rosenhouse-Dantsker A, Rohacs T and Logothetis DE. Protein Kinase A Modulates PLC-Dependent Regulation and PIP2 sensitivity of K+ channels. Channels 1: 124-134, 2007.
25. Thyagarajan, B., Lukacs, V., and Rohacs, T. Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium induced inactivation of TRPV6 channels. J.Biol.Chem 2008. 283:14980-14987
26. T. Rohacs, B. Thyagarajan, V. Lukacs: Phospholipase C mediated modulation of TRPV1 channels, Molecular Neurobiology, 2008, 37(2-3):153-63
27. Thyagarajan B, Benn BS, Christakos S, Rohacs T. Phospholipase C mediated regulation of TRPV6 channels: implications in active intestinal Ca2+ transport. Mol.Pharmacol. 2009. 75(3):608-16
28. Eleonora Zakharian, Baskaran Thyagarajan, Robert J. French, Evgeny Pavlov, and Tibor Rohacs: Inorganic polyphosphate modulates TRPM8 channels, PLoS ONE, 2009;4(4):e5404
29. Tibor Rohacs: Regulation of non-canonical transient receptor potential channels by phosphoinositides Cell Calcium 2009, 45: 554–565
30. Eleonora Zakharian, Chike Cao, Tibor Rohacs, Gating of TRPM8 channels activated by cold and chemical agonists in planar lipid bilayers, J. Neurosci 2010, 30(37):12526-34
31. Zakharian, E., Cao,C. Rohacs, T. Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5)P2, in press, FASEB J
32. Yudin, Y., Lukacs V., Cao C., Rohacs, T. Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates desensitization of the cold sensor TRPM8 channels, under revision,
33. Yudin, Y. Rohacs, T. Regulation of TRPM8 channel activity, Molecular and Cellular Endocrinology, (invited review) submitted
BOOK CHAPTERS
Mechanism of hormone action, in Nephrologia, Editors: Laszlo Rosivall, Istvan Kiss, Medintel Press, Budapest, 2003
Complex regulation of TRP channels by PIP2, in TRP channels in health and disease: implications for diagnosis and therapy. Editor: Arpad Szallasi, Nova Publishers, in press
T. Rohacs, N.Gamper, Ion channel regulation by phosphoinositides, in Handbook on Phosphoinositides, Editor, Tamas Balla, Springer, submitted
ABSTRACTS:
Over 35 published meeting abstracts
D. Research Support
Ongoing Research Support
1R01NS055159, National Institutes of Health, PI: T. Rohacs
Lipid Regulation of Transient Receptor Potential Channels
07/01/2007-05/31/2012 $218,750 / year direct cost
1 R01 GM093290, National Institutes of Health, PI: T. Rohacs
Regulation of the Intestinal Ca2+ channel TRPV6,
04/01/2011 – 03/31/2015 $190,000 / year direct cost
1R01 GM087369 National Institutes of Health, PI: Xinzhong Dong, Johns Hopkins University
“Functional Analysis of Pirt and Pirt2: novel regulators of TRP channels”
08/01/2010 – 07/31/2014 $30,000 / year direct cost subcontracted to T.R.
Completed Research Support
NRSA Postdoctoral fellowship
NIH
Detecting conformational changes in K+ channels using fluorescence spectroscopy
This award paid my salary during my postdoctoral fellowship for 1 year
Fellowship Award (Rohacs, PI) expired 6/30/2003
Revson Foundation $35000 / year for 2 years
Detecting conformational changes in K+ channels using fluorescence spectroscopy
Scientist Development Award 0330224N (Rohacs, PI) 01/01/2003 - 12/31/2006
American Heart Association
Growth factor regulation of inwardly rectifying K+ channels through phosphoinositide-3-kinases
Internal Award (Rohacs, PI) 06/01/ 2006 – 06/30/2007
UMDNJ Foundation $ 25,000 for one year
Direct regulation of phospholipase C by calcium channels
Sinsheimer Scholar Award (Rohacs, PI) 07/2006 -
Alexander and Alexandrine Sinsheimer Fund $50,000 / year for 3 years
UMDNJ Foundation (Rohacs, PI, Sylvia Christakos, PI)
Regulation of the intestinal Ca2+ channel TRPV6 by calcium binding proteins
08/01/2008 – 07/31/2009 $35,000 / 1 year