Pharmacology & Physiology

Recent Publications

 

Lee, H.Y., Choi, C.S., Birkenfeld, A.L., Alves, T.C., Jornayvaz, F.R., Jurczak, M.J., Zhang, D., Woo, D.K., Shadel, G.S., Ladiges, W., Rabinovitch, P.S., Santos, J.H., Petersen, K.F., Samuel, V.T., Shulman, G.I. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab. 2010 Dec 1;12(6):668-74.

Gordon, D.M., Santos, J.H. The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism. Journal of Nucleic Acids. Volume 2010, Article ID 390791, 7 pages, doi:10.4061/2010/390791.

Kovalenko, O.A., Kaplunov, J., Herbig, U., deToledo, S., Azzam, E.I., et al. (2010). Expression of NES-hTRT in Cancer Cells Delays Cell Cycle Progression and Increases Sensitivity to Genotoxic Stress. PLoS One 5(5):e10812.doi:10.1371/journal.pone.0010812.

Kovalenko, O.A., Caron, M.J., Ulema, P., Medrano, C., Thomas, A.P., Kimura, M., Bonini, M.G., Herbig, U., Santos, J.H.   A mutant telomerase defective in nulcear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell . 2010 Jan 18. [Epub ahead of print]

Kovalenko, O.A., Santos, J.H.  Analysis of oxidative damage by gene-specific quantitative PCR. Curr Protoc Hum Genet . 2009 Jul;Chapter 19:Unit 19.1.

Lu, B., Yadav, S., Shah, P.G., Liu, T., Tian, B., Pukszta, S., Villaluna, N., Kutejová, E., Newlon, C.S., Santos, J.H., Suzuki, C.K.   Roles for the human AT-dependent Lon protease in mitochondrial DNA maintenance. J Biol Chem . 2007 Jun 15;282(24):17363-74.

Chan, S.S., Santos, J.H., Meyer, J.N., Mandavilli, B.S., Cook, D.L. Jr., McCash, C.L., Kissling, G.E., Nyska, A., Foley, J.F., van Houten, B.,Copeland, W.C., Walker, V.E., Witt, K.L., Bishop, J.B. Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.  Environ Mol Mutagen. 2007 Apr-May;48(3-4):190-200

Santos, J.H., Meyer, J.N., Mandavilli, B.S., Van Houten, B.    Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol . 2006;314:183-99.

Santos, J.H., Meyer, J.N., Van Houten, B.  Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.  Hum Mol Genet . 2006 Jun 1;15(11):1757-68.

Stuart, G.R., Santos, J.H., Strand, M.K., Van Houten, B., Copeland, W.C. Mitochondrial andnuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia. Hum Mol Genet , 15 (2006):363-374.

Van Houten, B., Worshner, V. and Santos, J. H.. Role of mitochondria in toxic stress. DNA Repair , 5 (2006): 145-152 .

Santos, J. H., Meyer, J.N. and Van Houten, B. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Accepted for publication at Hum Mol Genet .

Santos, J. H., Meyer, J. N., Skorvaga, M. . Annab, L. A. and Van Houten, B. Mitochondrial hTERT exacerbates free radical-mediated mitochondrial DNA damage. Aging Cell, 3 (2004): 399-411.

Santos, J. H ., Hunakova, L., Chen, Y., Bortner, C. and Van Houten, B. Cell-sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death. Journal of Biological Chem.   278 (2003): 1728-1734.

Ingram, J. L., A. B. Rice, . Santos, J. H., Van Houten, B. and BONNER, J. C. Vanadium-induced HB-EGF Expression in Human Lung Fibroblasts is Oxidant- Dependent and Requires MAP Kinases . Am J Physiol Lung Cell Mol Physiol , 284 (2003): L774-L782.

Wang, Y-Z., Ingram, J. L., Walters, D., . RICE, A. B., Santos, J. H. Van Houten, B. and Bonner, J. Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and p38 MAP kinase. Free Radical Biology and Medicine, 35 (2003): 845-855 .

Gopalakrishnan, K., Santos, J. H., Grazciewicz, M. A., Copeland, W.C., Isaya, G., Van Houten, B. and Resnick, M. A. Reduction in frataxin causes progressive accumulation of mitochondrial damage, 24 (2003): 3331-3342 .

Mandavilli, B., Santos, J. H. and Van Houten, B. Mitochondrial DNA Repair and Aging . Mutation Research , 509 (2002): 127-151 .

Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC(Min/+) Mice.

Woo DK, Green PD, Santos JH, D'Souza AD, Walther Z, Martin WD, Christian BE, Chandel NS, Shadel GS.

Am J Pathol. 2011 Nov 2. [Epub ahead of print]

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria.

Sharma NK, Reyes A, Green P, Caron MJ, Bonini MG, Gordon DM, Holt IJ, Santos JH.

Nucleic Acids Res. 2011 Sep 29. [Epub ahead of print]