Pharmacology & Physiology
Recent Publications
N.D. Ullrich, M. Fanchaouy, K. Gusev, N. Shirokova and E. Niggli. (2009). Hypersensitivity of excitation-contraction coupling in dystrophic mdx mouse cardiomyocytes. American Journal of Physiology 297: H1992-2003.
M. Fanchaouy, E. Polakova, C. Jung, J. Ogrodnik, N. Shirokova and E. Niggli. (2009). Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes. Cell Calcium 46: 114-121.
V.M. Shkryl, A.S. Martins, N.D. Ullrich, M.C. Nowycky, E. Niggli and N. Shirokova. (2009). Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibers. Pflügers Archive 458: 915-928.
N. Shirokova and E. Niggli. Studies of RyR functions in situ. (2008). Methods, 3: 183-193.
W.J. Durham, P. Aracena-Parks, C. Long, A.E. Rossi, S.A. Goonasekera, S. Boncompagni, D.L. Galvan, C.P. Gilman, M. Baker, N. Shirokova, F. Protasi, R. Dirksen and S.L. Hamilton. (2008). RyR1 S-Nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knock-in mice. Cell, 133: 53-65.
C. Jung, A.S. Martins, E. Niggli and N. Shirokova. Dystrophic cardiomyopathy: amplification of cellular damage by Ca2+ signalling and reactive oxygen species-generating pathways. (2008). Cardiovascular Research, 77: 766-773.
A.S. Martins, V.M. Shkryl, M.C. Nowycky and N. Shirokova. Reactive oxygen species contribute to Ca2+ signals produced by osmotic stress in mouse skeletal muscle fibres. (2008). Journal of Physiology, 586: 197-210.
E. Niggli and N. Shirokova. (2007). A guide to sparkology: The taxonomy of elementary cellular Ca2+ signaling events. Cell Calcium, 42(4-5):379-387.
E.V. Isaeva, V.M. Shkryl and N. Shirokova. (2006). Ca2+ sparks: SOS signals of struggling muscle. Physiology News, 62: 27-28.
Shkryl VM and Shirokova N. (2006). Transfer and tunneling of Ca2+ from sarcoplasmic reticulum to mitochondria in skeletal muscle. Journal of Biological Chemistry, 281(3): 1547-1554.
Isaeva EV, Shkryl VM and Shirokova N. (2005). Mitochondrial redox state and Ca2+ sparks in permeabilized mammalian skeletal muscle. Journal of Physiology, 565: 855-872.
E.V.Isaeva and N. Shirokova. (2003). Metabolic regulation of Ca2+ release in permeabilized mammalian skeletal muscle fibres. Journal of Physiology, 547: 453-462.