Nucleic Acids Biochemistry

MSB-E675

Date

Day

Lecturer

1. Nucleic Acids: Structure and Genomes

09/04             

Th

L1

Historical Perspective                                                 

Modak

09/09

Tue

L2

DNA Structure

Coffman

09/11

Th

L3

DNA topology and topoisomerases

Coffman

09/16

Tue

L4

The Human genome

Bin Tian

09/18

Th

L5

Chromatin Structure and nucleosome assembly/remodeling

Lee, C. G.

09/23

Tue

L6

Mitochondrial genomes

Suzuki

09/25

Th

L7 

Viral genomes

Kaushik

09/30

Tue

Exam I

TAKE HOME  EXAM I

Lectures 1-7

2. Replication and Recombination

10/02

Th

L8

Replication in prokaryotes

Modak

10/07

Tue

L9

Replication in eukaryotes +
Mitochondrial Replication

Modak + Lee

10/09

Th

L10

Polymerase associated activities
(nuclease & pyrophosphorolsis)

Modak

10/14

Tue

L11

Reverse transcriptases

Pandey

10/16

Th

L12

Telomerase and terminal transferase

Pandey

10/21

Tue

L13

Nucleases

Kaushik

10/23

Th

L14

Genomic maintenance
(DNA damage and repair)

Lambert

10/28

Tue

L15

DNA Recombination mechanisms

Ripley

10/30

Th

Exam II

Take Home Exam II

Lectures 8-15

3.  Transcription and Translation

11/04

Tue

L16

RNA polymerases, prokaryotic activators
and repressors

Howells

11/06

Th

L17

Regulation of Transcription elongation

Pe’ery

11/11

Tue

L18

Genetic code, tRNAs and synthetases

Goldman

11/13

Th

L19

Prokaryotic translation mechanisms

Goldman

11/18

Tue

2008 GSA Conference

11/20

Th

L21

Ribosome recruitment and Alternative
mechanisms of recruitment

Mathews

11/25

Tue

L22 + Exam III 

Eukaryotic translational control mechanisms.

Mathews

11/27

Th

Thanksgiving Holiday

4. Transcription and Regulation

12/02

Tue

L23

Pre-mRNA splicing and polyadenylation,
capping, decapping

Lutz

12/04

Th

L24

mRNA modification: and editing and transport

O’Connor

12/09

Tue

L25

RNAi,  miRNA, siRNA and nc RNA

Lutz

12/11

Th

L26

Eukaryotic activators and repressors

Rogers

12/16

Tue

L27

Transcriptional regulation

Kotenko

12/16

Tue

Exam IV

Take Home Exam IV

All students

TBA

FINAL GRADE DISTRIBUTION and Party