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Fundamentals of Biomedical Sciences I: Biochemistry and Molecular Biology
(Course GSND N500A) - 2011

Fall 2011, Tuesdays,  6:00 to 9:00 p.m. Room B556, Medical Science Bldg.
Instructor: Michael A. Lea, Ph.D., Telephone: 973-972-5345, Fax: 973-972-5594
e-mail lea@umdnj.edu,      Office: Room E649

COURSE OUTLINE: This course covers basic biochemistry and molecular biology. The nature of the major macromolecules will be discussed and their role in the regulation of carbohydrate, lipid and amino acid metabolism will be illustrated. The synthesis of proteins and nucleic acids will be reviewed and the experimental techniques used in molecular biology will be considered. A review of the regulation of gene expression and intermediary metabolism will serve as an introduction to a more extensive consideration of the material to be discussed in the cell biology course in the following semester. Throughout the course an effort will be made to indicate the relevance of biochemistry to clinical medicine.

DATE                                                 TITLE
_______________________________________________________________
Sept. 6            Introduction - Functional Groups in Biological Molecules, Amino Acids
Sept. 13         Protein Structure and Function; Enzymes: Kinetics and Regulation
Sept. 20         Carbohydrates and Nucleotide Structure, Glycolysis and Gluconeogenesis
Sept. 27         Pentose Phosphate Pathway, Glycogen and Glycosaminoglycans
Oct. 4              Bioenergetics and the Tricarboxylic Acid Cycle; Electron Transport and Oxidative Phosphorylation

Oct. 11            Lipid metabolism and Review - Lipid metabolism part 2
Oct. 18            No class
Oct. 25            Examination 1
Nov. 1             Amino Acid Metabolism, Protein Turnover and the Urea Cycle Porphyrins and Hemoglobin

Nov. 8            Nucleotide Metabolism and DNA Synthesis
Nov. 15          RNA and Protein Synthesis
Nov. 22          Techniques in Molecular Biology - Plasma Protein and Blood Clotting
Nov. 29          Regulation of Gene Expression and Intermediary Metabolism
                      Regulation of Metabolism    -        HORMONAL SIGNALING
Dec. 6             Review
Dec. 13          Examination 2

Suggested Text:  Lippincott’s Illustrated Reviews: Biochemistry, 5th edition, 2011, by Harvey and Ferrier, published by Lippincott Williams and Wilkins, Philadelphia or Principles of Medical Biochemistry, 3rd edition by G. Meisenberg and W.H. Simmons, Elsevier – Saunders, 2012

Points:            Exam 1 and 2, 50% each. There are no extra credit items.