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Molecular Medicine of the Heart - CBMM 5350Q
General Information
Fall 2010
Tuesday
9:00 AM – 12:00 PM
Sep 7, 2010 - December 14, 2010
Room MSB B-619
Recommended Text:
The course will be based on: Opie LH, “Heart Physiology”, 4rd edition, Lippincott-Williams Wilkins.
Course Description:
The course is open to all students in the GSBS Graduate Programs and in the Masters Program. It will address the mechanisms of heart function and dysfunction in an integrated approach including morphology, physiology, biochemistry, molecular biology, pharmacology and the basics of cardiovascular disease. The lectures will cover the following topics:
- Structure of the heart
- Physiology and electrophysiology
- Excitation-contraction coupling
- Coronary flow and oxygen supply
- Metabolism
- Cardiac signaling
- Gene and protein response to stress in the normal heart
- Vascular biology, cholesterol and atherosclerosis
- Hypertrophic response: the athlete’s heart versus the hypertensive heart
- Maladaptation to disease: ischemic injury and infarction
- End-stage of disease: heart failure
- Clinical correlate to ischemia and infarction
- Clinical correlate to hypertrophy and heart failure
Active learning:
At each class, the students will take a quiz (3 to 4 questions) about the material covered in the previous lecture. These quizzes are corrected by the instructor and given back to the students the following week. These mandatory quizzes are extremely helpful to stimulate the students to frequent revisions of the material, to pinpoint possible areas of weakness, and to get used to the format of the questions presented at the exams.
Grading Policy:
Evaluation will be based on written answers to questions (both mid-term and final) related to the different topics.
Midterm – 35%
Final – 65%
Note: the final exam covers the entire course
Note: Make-up exams will not be given without a letter from a physician.
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