Andrew P. Thomas, Ph.D.

Research Interest

 

· Hajnóczky, G., Robb-Gaspers, L.D., Seitz, M.B. and Thomas, A.P. (1995)  Decoding of cytosolic calcium oscillations in the mitochondria.  Cell. ⁸², 415-424

 

· Robb-Gaspers, L.D., Rutter, G.A., Burnett, P.B., Rizzuto, R.S., Denton, R.M. and Thomas, A.P. (1998) Regulation of hepatic mitochondrial metabolism by Ca²⁺-dependent hormones.  EMBO J. ¹⁷, 4987-5000.

 

· Csordás, G., Thomas, A.P. and Hajnóczky, G.  (1999)  Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria.  EMBO J. ¹⁸, 96-108.

 

· Patel, S., Robb-Gaspers, L.D., Stellato, K.A., Shon, M. and Thomas, A.P. (1999)  Coordination of Ca²⁺ signaling by endothelial-derived nitric oxide in the intact liver.  Nature Cell Biol. ¹, 467-471.

 

· Smaili, S.S., Stellato, K.A., Burnett, P., Thomas, A.P. and Gaspers, L.D.  (2001) Cyclosporin A inhibits Inositol 1,4,5-trisphosphate-dependent Ca²⁺ signals by enhancing Ca²⁺ uptake into the ER and mitochondria.  J. Biol. Chem. ²⁷⁶, 23329-23340.

 

· Pacher, P., Thomas, A.P. and Hajnóczky, G. (2002)  Miniature calcium signals in single mitochondria driven by ryanodine receptors.  Proc. Natl. Acad. Sci. USA.  ⁹⁹, 2380-2385.

 

· Patel, S., Gaspers, L.D., Boucherie, S., Memin, E., Stellato, K.A., Guillon, G., Combettes, L. and Thomas, A.P.  (2002)  Inducible nitric oxide synthase attenuates vasopressin-dependent Ca²⁺ signalling in rat hepatocytes.  J. Biol. Chem. ²⁷⁷, 33776-33782.

 

· Tsuboi, T., Da Silva Xavier, G., Holz, G.G., Jouaville, L.S., Thomas, A.P. and Rutter, G.A.  (2003) Glucagon-like peptide-1 mobilizes intracellular Ca²⁺ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 b-cells.  Biochem. J. ³⁶⁹, 287-299.

 

· Gazarini, M.L., Thomas, A.P., Pozzan, T. and Garcia, C.R.S. (2003) Calcium signaling in a low calcium environment: How the intracellular malaria parasite solves the problem.  J. Cell Biol.  ¹⁶¹, 103-110.

 

· Yan, L., Ge, H., Li, H., Lieber, S., Natividad, F., Resuello, R.R.G., Kim, S.J., Akeju, S., Sun, A., Loo, K., Peppas, T., Rossi, F., Lewandowski, E.D., Thomas, A.P., Vatner, S.F. and Vatner, D.E.  (2004) Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts.  J. Mol. Cell. Cardiol. ³⁷, 921-929.

 

· Gaspers, L.D. and Thomas, A.P. (2005) Calcium signaling in liver.  Cell Calcium. ³⁸, 329-342.

 

· Politi, A., Gaspers, L.D., Thomas, A.P. Höfer, T.  (2006)  Model of IP³ and Ca²⁺ oscillations: Frequency encoding and identification of underlying feedbacks.  Biophys. J. Feb 24; [Epub ahead of print].